Title

Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate phases

Document Type

Article

Publication Date

Spring 3-12-2012

Abstract

Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral anti-cancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Solubility measurements conducted in water reveal the anhydrate has dramatically improved solubility compared to the commercial hydrate form. Finally, dasatinib is a rare example of a promiscuous solvate former and the basis for this behavior can now be understood by examining the poor packing efficiency in the unsolvated form.

Comments

The Version of Record is available from the publisher at http://pubs.acs.org/doi/abs/10.1021/cg300152p. Copyright © 2012 American Chemical Society. All rights reserved.

doi:10.1021/cg300152p