Assembly and Function of Myosin II on Ultraviolet/Ozone Patterned Trimethylchlorosilane Substrates

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The study of biomolecular motors represents a rapidly and progressing field of nanobiotechnology. Here, we present a simple method for patterning myosin II on a microstructured surface. Our findings indicate that UV/ozone treatment can be used to alter the hydrophobicity of trimethyl-chloro-silane (TMCS) coated glass surfaces, to alter protein binding, and effectively produce localized motor activity. Taken together, these data suggest that photoreactive patterning may be useful for the selective localization of functional myosin II motor tracks.


This article first appeared in the June 2008 issue of Journal of Bionanoscience, the member magazine of the American Scientific Publishers, and is reprinted with permission. DOI: http://dx.doi.org/10.1166/jbns.2008.024

Copyright © 2008 American Scientific Publishers