"Aligned-to-random’’ Nanofiber Scaffolds for Mimicking the Structure of the Tendon-to-Bone Insertion Site

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We have demonstrated the fabrication of “aligned-to-random” electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.


Xie J., Li X., Lipner J., Manning C.N., Schwartz A.G., Thomopoulos, S. et al. "Aligned-to-random” nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site. Nanoscale, 2 (6) (2010), pp. 923–926. DOI: 10.1039/C0NR00192A

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© Royal Society of Chemistry 2012