Marshall Digital Scholar

Title

Roll-in Experience from the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) Study

Authors

Timothy P. Murphy MD
Christopher J. Cooper MD
Donald E. Cutlip MD
Alan Matsumoto MD
Kenneth Jamerson MD
John Rundback MD
Kenneth A. Rosenfield MD
William Henrich
Joseph I. Shapiro MD, Marshall UniversityFollow
Joseph Massaro PhD
Chen-Hsing Yen MS
Holly Burtch RN
Claudia Thum MS
Diane Reid MD
Lance Dworkin MD

Document Type

Article

Publication Date

2014

Abstract

Purpose: To describe the experience and results from the roll-in phase of the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study.

Materials and Methods: The CORAL roll-in database was used to describe the baseline characteristics of the patients in the roll-in cohort, all of whom underwent renal artery stent placement; to evaluate CORAL site performance; to compare estimates of lesion (stenosis) severity made by site interventionalists with the central CORAL angiographic core laboratory readings; and to report outcomes after renal artery stent placement. During the roll-in phase, 239 patients (mean age, 70.2 y _ 9.0; 49% male) underwent renal artery stent procedures. Angiographic core laboratory analysis of renal arteriograms was done, and participants were followed at 1 month and 9 months.

Results: Major angiographic complications were identified in 28 (13%) subjects. Kidney function remained unchanged at the short (2–4 weeks) follow-up interval. Improvement in systolic blood pressure with use of distal embolic protection devices (n ¼161) did not show any clinical benefit over nonuse of such devices (n ¼ 78) in this small series. At 9 months, there were significantly more endpoints reported by site in subjects with bilateral renal artery stenosis (P ¼ .01) and prior history of stroke (P ¼ .03).

Conclusions: In the roll-in phase of the CORAL study, a significant number of angiographic complications were identified. No effect was seen on estimated glomerular filtration rate after renal artery stent placement, but systolic blood pressure decreased significantly.

Comments

Open access to this article is provided by the Journal of Vascular and Interventional Radiology, the official journal of the Society of Interventional Radiology at http://www.jvir.org/article/S1051-0443(13)01452-8/abstract. Copyright 2014 Society of Interventional Radiology. All rights reserved. DOI: 10.1016/j.jvir.2013.12.569

Recommended Citation

Murphy TP, CJ Cooper, DE Cutlip, A Matsumoto, K Jamerson, J Rundback, KA Rosenfield, W Henrich, J Shapiro, J Massaro, CH Yen, H Burch, C Thum, D Reid, L Dworkin. 2014. Roll in experience from the cardiovascular outcomes with renal atherosclerotic lesions (CORAL) study. J. Vasc. Interv. Radiol. 25:511-20. PMID:24325931.