Title

Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosaAnionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa

Document Type

Article

Publication Date

Spring 2-15-2016

Abstract

Pseudomonas aeruginosa is a common biofilm-forming bacterial pathogen implicated in diseases of the lungs. The extracellular polymeric substances (EPS) of respiratory Pseudomonas biofilms are largely comprised of anionic molecules such as rhamnolipids and alginate that promote a mucoid phenotype. In this Letter, we examine the ability of negatively-charged fluoroquinolones to transverse the EPS and inhibit the growth of mucoid P. aeruginosa. Anionic fluoroquinolones were further compared with standard antibiotics via a novel microdiffusion assay to evaluate drug penetration through pseudomonal alginate and respiratory mucus from a patient with cystic fibrosis.

Comments

The version of record is available from the publisher at https://doi.org/10.1016/j.bmcl.2016.01.012. Copyright © 2016 Elsevier Ltd. All rights reserved.