Title
The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases
Document Type
Article
Publication Date
2016
Abstract
The Na/K-ATPase has been extensively studied, but it is only recently that its role as a scaffolding and signaling protein has been identified. It has been identified that cardiotonic steroids (CTS) such as digitalis mediate signal transduction through the Na/K-ATPase in a process found to result in the generation of reactive oxygen species (ROS). As these ROS also appear capable of initiating this signal cascade, a feed forward amplification process has been postulated and subsequently implicated in some disease pathways including uremic cardiomyopathy.
Recommended Citation
Yan Y, Shapiro JI. The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Current opinion in pharmacology 2016;27:43-49
Comments
The copy of record is available from the publisher at https://doi.org/10.1016/j.coph.2016.01.009. Copyright © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/