Title
The trade-off between dietary salt and cardiovascular disease; a role for Na/K-ATPase signaling?
Document Type
Article
Publication Date
Summer 7-17-2014
Abstract
It has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and tissue concentrations have been made. More recently, it has been identified that CTS also mediate signal transduction through the Na/K-ATPase, and consequently been implicated in profibrotic pathways. This review will discuss the mechanism of CTS in renal sodium handling and a potential “trade-off” effect from their role in inducing tissue fibrosis.
Recommended Citation
Xie JX, Shapiro AP, Shapiro JI. The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling? Frontiers in Endocrinology 2014;5(97)
Comments
The copy of record is available from the publisher at http://dx.doi.org/10.3389/fendo.2014.00097. Copyright © 2014 Xie, Shapiro and Shapiro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.