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Research from 2017

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Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase-dependent connexin43 phosphorylation, Lise Hangaard, Elena V. Bouzinova, Christian Staehr, Vibeke S. Dam, Sukhan Kim, Zijian Xie, Christian Aalkjaer, and Vladimir V. Matchkov

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3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells, Yaomin Wang, Casey Compton, Gary O. Rankin, Stephen J. Cutler, Yon Rojanasakul, Youying Tu, and Yi Charlie Chen

Research from 2016

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4-Amino-2-chlorophenol: Comparative In Vitro Nephrotoxicity and Mechanisms of Bioactivation, Gary O. Rankin, Adam Sweeney, Christopher Racine, Travis Ferguson, Deborah Preston, and Dianne K. Anestis

Research from 2015

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The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway, Jianchu Chen, Allen Y. Chen, Haizhi Huang, Xingqian Ye, William D. Rollyson, Haley E. Perry, Kathleen C. Brown, Yon Rojanasakul, Gary O. Rankin, Piyali Dasgupta, and Yi Charlie Chen

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Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis, Haizhi Huang, Allen Y. Chen, Yon Rojanasakul, Xingqian Ye, Gary O. Rankin, and Yi Charlie Chen

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Insulin/Insulin-like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies, Travis B. Salisbury

Research from 2014

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Evaluation of Skin Permeation of β-blockers for Topical Drug Delivery, Doungdaw Chantasart, Jinsong Hao, and S. Kevin Li

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Influence of Drug Lipophilicity on Drug Release from Sclera after Iontophoretic Delivery of Mixed Micellar Carrier System to Human Sclera, Poonam Chopra, Jinsong Hao, and S. Kevin Liu

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Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice, Christopher A. Drummond, Moustafa Sayed, Kaleigh L. Evans, Huilin Shi, Xiaoliang Wang, Steven T. Haller, Jiang Liu, Christopher J. Cooper, Zijian Xie, Joseph I. Shapiro MD, and Jiang Tian

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Assessment of PLGA-PEG-PLGA Copolymer Hydrogel for Sustained Drug Delivery in the Ear, Liang Feng, Jonette A. Ward, S. Kevin Li, Gaurav Tolia, Jinsong Hao, and Daniel I. Choo

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Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells, Zhiping He, Bo Li, Gary O. Rankin, Yon Rojanasakul, and Yi Charlie Chen

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Synthesis and antimalarial activity of metal complexes of cross- bridged tetraazamacrocyclic ligands, Timothy J. Hubin, Prince N. -A Amoyaw, Kimberly D. Roewe, Nathalie C. Simpson, Randall D. Maples, TaRynn N. Carder Freeman, Amy N. Cain, Justin G. Le, Stephen J. Archibald, Shabana I. Khan, Babu L. Tekwani, and M. O. Faruk Khan

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HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets, Zeid Khitan, Mohit Harsh, Komal Sodhi, Joseph I. Shapiro MD, and Nader G. Abraham

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Evaluation of intratympanic formulations for inner ear delivery: methodology and sustained release formulation testing, Hongzhuo Liu, Liang Feng, Gaurav Tolia, Mark R. Liddell, Jinsong Hao, and S. Kevin Li

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Fatal methadone toxicity: potential role of CYP3A4 genetic polymorphism, Lauren L. Richards-Waugh PhD, Donald A. Primerano PhD, Yulia Dementieva, James C. Kraner, and Gary O. Rankin PhD

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In vitro Metabolic Stability Study of New Cyclen Based Antimalarial Drug Leads Using RP-HPLC and LC-MS/MS, Apoorva V. Rudraraju, Mohammad F. Hossain, Anjuli Shrestha, Prince N.A. Amoyaw, Babu L. Tekwani, and M. O. Faruk Khan

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Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors?, Antonios H. Tzamaloukas MD; Joseph I. Shapiro MD; Dominic S. Raj MD; Glen H. Murata MD; Robert H. Glew PhD; and Deepak Malhotra MD, PhD

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Characterization of Human Sclera Barrier Properties for Transscleral Delivery of Bevacizumab and Ranibizumab, He Wen, Jinsong Hao, and S. Kevin Li

Research from 2013

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Sustained Release Micellar Carrier Systems for Iontophoretic Transport of Dexamethasone across Human Sclera, Poonam Chopra, Jinsong Hao, and S. Kevin Li

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Peroxisome proliferator-activated receptor delta agonist, HPP593, prevents renal necrosis under chronic ischemia, Larisa V. Fedorova, Komal Sodhi, Cara Gatto-Weis, Nitin Puri, Terry D. Hinds Jr., Joseph I. Shapiro MD, and Deepak Malhotra

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Effect of CD40 and sCD40L on Renal Function and Survival in Patients with Renal Artery Stenosis, Steven T. Haller Ph.D; Philip A. Kalra MD; James P. Ritchie MD; Tina Chrysochou MD, Ph.D.; Pamela Brewster MA; Wencan He MS; Haifeng Yu MS; Joseph I. Shapiro MD; and Christopher J. Cooper MD

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A Standardized Patient Counseling Rubric for a Pharmaceutical Care and Communications Course, Niambi Horton PharmD, Kenna D. Payne PharmD, Michelle Jernigan PharmD, Jill Frost PharmD, Stephen Wise PharmD, Mary Klein PharmD, Joel Epps MBA, and H. Glenn Anderson PharmD

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CD36 and Na/K-ATPase- α 1 Form a Proinflammatory Signaling Loop in Kidney, David J. Kennedy, Yiliang Chen, Wenxin Huang, Jamie Viterna, Jiang Liu, Kristen Westfall, Jian Tian, David J. Bartlett, W.H. Wilson Tang, Zijian Xie, Joseph I. Shapiro MD, and Roy L. Silverstein

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An Update on BRAF Inhibitors and Other New Molecular Targets for the Treatment of Malignant Melanoma of the Skin, M. O. Faruk Khan and Carroll L. Ramos

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Current Strategies for Drug Delivery to the Inner Ear, Hongzhuo Liu, S. Kevin Li, and Jinsong Hao

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Principles of Management of Severe Hyponatremia, Antonios H. Tzamaloukas MD; Deepak Malhorta MD, PhD; Bradley H. Rosen DO; Dominic S. C. Raj S. C. Raj MD; Glen H. Murata MD; and Joseph I. Shapiro MD

Research from 2012

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Ouabain and Insulin Induce Sodium Pump endocytosis in Renal Epithelium, Shalini Gupta, Yanling Yan, Deepak Malhotra, Jiang Liu, Zijian Xie, Sonia M. Najjar, and Joseph Shapiro

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Effects of Organic Solvents on the Barrier Properties of Human Nail, Jinsong Hao, S. Kevin Li, and Kelly A. Smith

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MRI Study of Subconjunctival and Intravitreal Injections, S. Kevin Li, Jinsong Hao, Hongshan Liu, and Jing-Huei Lee

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Brain distribution and elimination of recombinant human TIMP-1 after cerebral ischemia and reperfusion in rats, Yalian Sa, Jinsong Hao, Divya Samieneni, Joseph Clark, Gail Pyne-Geithman, Joseph Broderick, and Aigang Lu

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Ouabain-Stimulated Trafficking Regulation of the Na/K-ATPase and NHE3 in Renal Proximal Tubule Cells, Yanling Yan, Steven Haller, Anna Shapiro, Nathan Malhotra, Jiang Tian, Zijian Xie, Deepak Malhotra, Joseph I. Shapiro MD, and Jiang Liu

Research from 2011

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High fat diet enhances cardiac abnormalities in SHR rats: Protective role of heme oxygenaseadiponectin axis, Jian Cao, Komal Sodhi, Nitin Puri, Sumit R. Monu, Rita Rezzani, and Nader G. Abraham

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Iontophoretic Transport of Charged Macromolecules across Human Sclera, Poonam Chopra, Jinsong Hao, and S. Kevin Li

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Time-Dependent Electrical Properties of Human Nail Upon Hydration In Vivo, Jinsong Hao, Kelly A. Smith, and S. Kevin Liu

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Distribution of Propranolol in Periocular Tissues: A Comparison of Topical and Systemic Administration, Jinsong Hao, Michael B. Yang, Hongzhou Liu, and S. Kevin Li

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Endogenous cardiotonic steroids in chronic renal failure, Elena V. Kolmakova, Steven T. Haller, David J. Kennedy, Alina N. Isachkina, George V. Budny, Elena V. Frolova, Grzegorz Piecha, Elena R. Nikitina, Deepak Malhotra, Joseph I. Shapiro MD, and Alexei Y. Bagrov

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Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling, Jiang Liu, David J. Kennedy, Yanling Yan, and Joseph I. Shapiro MD

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Impairment of Na/K-ATPase Signaling in Renal Proximal Tubule Contributes to Dahl salt-sensitive Hypertension, Jiang Liu, Yanling Yan, Lijun Liu, Zijian Xie, Deepak Malhotra, Bina Joe, and Joseph I. Shapiro

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In-vitro Antiproliferative Activity of Benzopyranone Derivatives in Comparison with Standard Chemotherapeutic Drugs, Musiliyu A. Musa, John S. Cooperwood, M. O. Faruk Khan, and Taufiq Rahman

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Influence of pH on Transungual Passive and Iontophoretic Transport, Kelly A. Smith, Jinsong Hao, and S. Kevin Li

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Influence of Permeant Lipophilicity on Permeation Across Human Sclera, He Wen, Jinsong Hao, and S. Kevin Li

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Determinants of renal function in patients with renal artery stenosis, Haifeng Yu, Dong Zhang, Steven Haller, Khalil Kanjwal, William Colyer, Pamela Brewster, Michael Steffes, Joseph I. Shapiro MD, and Christopher J. Cooper

Research from 2010

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Electrically assisted delivery of macromolecules into the corneal epithelium, Jinsong Hao, S. Kevin Li, Chia Lang Liu, and Winston W.Y. Kao

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Gene delivery to cornea, Jinsong Hao, S. Kevin Li, and Chia Yang Liu

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Iontophoretically Enhanced Ciclopirox Delivery into and Across Human Nail Plate, Jinsong Hao, S. Kevin Li, and Kelly A. Smith

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The Sodium Pump and Cardiotonic Steroids-induced Signal Transduction Protein Kinases and Calcium-signaling Microdomain in Regulation of Transporter Trafficking, Jiang Liu

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Synthesis and Antimicrobial Activity of N,N′-Bis(2-hydroxylbenzyl)-1,2-ethanediamine Derivatives, Musiliyu A. Musa, M. O. Faruk Khan, Arden Aspedon, and John S. Cooperwood

Research from 2009

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Why Patients Need Protection From the Sun, M. O. Faruk Khan and W. Steve Pray

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Effects of Ionic Strength on Passive and Iontophoretic Transport of Cationic Permeant Across Human Nail, Kelly A. Smith, Jinsong Hao, and S. Kevin Li

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Effects of Alternating Current Frequency and Permeation Enhancers Upon Human Epidermal Membrane, Qingfang Xu, Rajan P. Kochambilli, Yang Song, Jinsong Hao, William I. Higuchi, and S. Kevin Li

Research from 2008

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Use of multiple fluorophores for evaluating microvascular permeability in control and septic rats, Ragheb A. Assaly, Robert H. Habib, Mustafa Azizi, Joseph I. Shapiro MD, and David Dignam

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Regulation of Apical NHE3 Trafficking by Ouabain-Induced Activation of Basolateral Na/K-ATPase Receptor Complex, Haiping Cai, Liang Wu, Weikai Qu, Deepak Malhotra, Zijian Xie, Joseph I. Shapiro, and Jiang Liu

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Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress, Jian Cao, George Drummond, Kazuyoshi Inoue, Komal Sodhi, Xiao Ying Li, and Shinji Omura

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Embolic Protection and Platelet Inhibition During Renal Artery Stenting, Christopher J. Cooper MD, Steven T. Haller MS, William Colyer MD, Michael Steffes MD, Mark W. Burket MD, William J. Thomas MD, Robert Safian MD, Bhagat Reddy MD, Pamela Brewster MA, Mary Ann Ankenbrandt MD, Renu Vermani MD, Eric Dippel MD, Krishna Rocha-Singh MD, Timothy P. Murphy MD, David J. Kennedy PhD, Joseph I. Shapiro MD, Ralph D. D'Agostino PhD, Michael J. Pencina PhD, and Sadik Khuder PhD

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Mechanistic Study of Electroosmotic Transport Across Hydrated Nail Plates: Effects of pH and Ionic Strength, Jinsong Hao and S. Kevin Li

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Transungual Iontophoretic Transport of Polar Neutral and Positively Charged Model Permeants: Effects of Electrophoresis and Electroosmosis, Jinsong Hao and S. Kevin Li

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Chemical Method to Enhance Transungual Transport and Iontophoresis Efficiency, Jinsong Hao, Kelly A. Smith, and S. Kevin Li

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Synthesis and Pharmacology of Anti-inflammatory Steroidal Antedrugs, M. O. Faruk Khan and Henry J. Lee

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A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer, Musiliyu A. Musa, John S. Cooperwood, and M. Omar Faruk Khan

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Silicone Elastomer Uptake Method for Determination of Free 1-Alkyl-2-Pyrrolidone Concentration in Micelle and Hydroxypropyl-b-Cyclodextrin Systems Used in Skin Transport Studies, Kevin S. Warner, Dalia S. Shaker, Sarah Molokhia, Qingfang Xu, Jinsong Hao, William I. Higuchi, and S. Kevin Li

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Alternating Current (AC) Iontophoretic Transport across Human Epidermal Membrane: Effects of AC Frequency and Amplitude, Guang Yan, Qingfang Xu, Yuri G. Anissimov, Jinsong Hao, William I. Higuchi, and S. Kevin Li

Research from 2007

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Partial nephrectomy as a model for uremic cardiomyopathy in the mouse, David J. Kennedy, Jihad Elkareh, Amjad Shidyak, Anna P. Shapiro, Sleiman Smaili, Krishna Mutgi, Shalini Gupta, Jiang Tian, Eric Morgan, Samer Khouri, Christopher J. Cooper, Sankaridrug M. Periyasamy, Zijian Xie, Deepak Malhorta, Olga V. Fedorova, Alexei Y. Bagrov, and Joseph I. Shapiro MD

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Trypanothione Reductase: A Viable Chemotherapeutic Target for Antitrypanosomal and Antileishmanial Drug Design, M. O. Faruk Khan

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Effect of Standard Treatment Guidelines with or without Prescription Audit on Prescribing for Acute Respiratory Tract Infection (ARI) and Diarrhoea in some Thana Health Complexes (THCs) of Bangladesh, M. O. Faruk Khan, A.K. Azad Chowdhury, M. A. Matin, K. Begum, and M. A. Galib

Research from 2005

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Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy, David J. Kennedy, Sandeep Vetteth, Sankaridrug M. Periyasamy, Mohamed Kanj, Larisa Fedorova, Samer Khouri, M. Bashar Kahaleh, Zijian Xie, Deepak Malhotra, Nikolai I. Kolodkin, Edward G. Lakatta, Olga V. Fedorova, Alexei Y. Bagrov, and Joseph I. Shapiro MD

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GRP78/BIP is Involved in Ouabain-Induced Endocytosis of the Na/K-ATPase in LLC-PK1 Cells, Riad Kesiry and Jiang Liu

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Ouabain-induced Endocytosis and Signal Transduction of the Na/K-ATPase, Jiang Liu

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Ouabain-induced Endocytosis of the Plasmalemmal Na/K-ATPase in LLC-PK1 Cells Requires Caveolin-1, Jiang Liu, Man Liang, Lijun Liu, Deepak Malhotra, Zijian Xie, and Joseph I. Shapiro

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Cardiac Glycoside Downregulates NHE3 Activity and Expression in LLC-PK1 Cells, Shadi Oweis, Liang Wu, Pawel R. Kiela, Deepak Malhotra, Fayez K. Ghishan, Zijian Xie, Joseph I. Shapiro, and Jiang Liu

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Antitrypanosomal, Antileishmanial, and Antimalarial Activities of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, a New Class of Trypanothione Reductase Inhibitor, and of N-Acyl Derivatives of 2-Amino-4-Chlorophenyl Phenyl Sulfide, Seheli Parveen, M. O. Faruk Khan, Susan E. Austin, Simon L. Croft, Vanessa Yardley, Peter Rock, and Kenneth T. Douglas

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Salt Loading Induces Redistribution of the Plasmalemmal Na/K-ATPase in Proximal Tubule Cells, Sankaridrug M. Periyasamy, Jiang Liu, Feras Tanta, BEsher Kabak, Brent Wakefield, Deepak Malhorta, David j. Kennedy, Alaa Nodoor, Olga V. Fedorova, William Gunning, Zijian Xie, Alexi Y. Bagrov, and Joseph I. Shapiro

Research from 2004

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Mechanisms for Aldosterone and Spironolactone-Induced Positive Inotropic Actions in the Rat Heart, John C. Barbato, Sumia Rashid, Patrick J. Mulrow, Joseph I. Shapiro MD, and Roberto Franco-Saenz

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Probing Proteinase Active Sites Using Oriented Peptide Mixture Libraries – ADAM-10, John L. Krstenansky, Jihong Wang, Gregg R. Chenail, Matthew R. Tiffany, Geoffrey M. Kuesters, Barbara C. Natke, and John L. Nestor Jr.

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Ouabain Induces Endocytosis of Plasmalemmal Na/K-ATPase in LLC-PK1 Cells by a Clathrin-dependent Mechanism, Jiang Liu, Riad Kesiry, Sankaridrug M. Periyasamy, Deppak Malhorta, Zijian Xie, and Joseph I. Shapiro

Research from 2002

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Effects of Cardiac Glycosides on Sodium Pump Expression and Function in LLC-PK1 and MDCK Cells, Jiang Liu, Sankaridrug M. Periyasamy, William Gunning, Olga V. Fedorova, Alexi Y. Bagrov, Deepak Malhorta, Zijian Xie, and Joseph I. Shapiro

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A Study of 5-aminolevulinic Acid and its Methyl Ester Used in In vitro and In vivo Systems of Human Bladder Cancer, Vanaja Manivasager, Paul Wan Sia Heng, Jinsong Hao, Wei Zheng, Khee Chee Soo, and Malini Olivo

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Macro-microscopic Fluorescence Imaging of Human NPC Xenografts in a Murine Model Using Topical vs. Intravenous Administration of 5-Aminolevulinic Acid, Vanaja Manivasager, Paul Wan Sia Heng, Jinsong Hao, Wei Zheng, Khee Chee Soo, and Malini Olivo

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Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga V. Fedorova, Alexei Y . Bagrov, Jiang Liu, Sankaridrug M. Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, and Joseph I. Shapiro MD

Research from 2001

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Initial Evidence of Endothelial Cell Apoptosis as a Mechanism of Systemic Capillary Leak Syndrome, Ragheb Assaly MD; Dan Olson MD, PhD, FCCP; Jeffrey Hammersley MD, FCCP; Pan-Sheng Fan MD; Jiang Liu PhD; Joseph I. Shapiro MD; and M. Bashar Kahaleh MD

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Rapid Effects of Aldosterone and Spironolactone in the Isolated Working Rat Heart, John C. Barbato, Patrick J. Mulrow, Joseph I. Shapiro MD, and Roberto Franco-Saenz

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Effects of enhanced oxygen release from hemoglobin by RSR13 in an acute renal failure model, Thomas J. Burke, Deepak Malhorta, and Joseph I. Shapiro MD

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Cardiac performance in inbred rat genetic models of low and high running capacity, J. Chen, G. M. Feller, J. C. Barbato, S. Periyasamy, Zijian Xie, L. G. Koch, Joseph I. Shapiro MD, and S. L. Britton

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Effect of Chronic Renal Failure on Cardiac Contractile Function, Calcium Cycling, and Gene Expression of Proteins Important for Calcium Homeostasis in the Rat, David Keenedy, Eiad Omran, Sankaridrug M. Periyasamy, Jalaa Nadoor, Anumeet Priyadarshi, James C. Wiley, Deepak Malhotra, Jingwei Xie, and Joseph I. Shapiro MD

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Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function, Sankaridrug M. Periyasamy, Jie Chen, Derek Cooney, Patricia Carter, Eiad Omran, Jiang Tian, Snigdha Priyadarshi, Alexei Bagrov, Olga Fedorova, Deepak Malhotra, Zijian Xie, and Joseph I. Shapiro MD

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Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat, Anumeet Priyadarshi, Sankaridrug Periyasamy, Thomas J. Burke, Steven L. Britton, Deepak Malhorta, and Joseph I. Shapiro MD

Research from 2000

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Use of an Additional Hydrophobic Binding Site, the Z Site, in the Rational Drug Design of a New Class of Stronger Trypanothione Reductase Inhibitor, Quaternary Alkylammonium Phenothiazines, M. O. Faruk Khan, Susan E. Austin, Cecil Chan, Hong Yin, Debora Marks, Sheetal N. Vaghjiani, Howard Kendrick, Vanessa Yardley, Simon L. Croft, and Kenneth T. Douglas

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Ouabain Interaction with Cardiac Na+/K+-ATPase Initiates Signal Cascades Independent of Changes in Intracellular Na+ and Ca2+, Jiang Liu, Jiang Tian, Michael Haas, Joseph I. Shapiro, Amir Askari, and Zijian Xie

Research from 1999

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Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and its Marker Genes in Cardiac Myocytes, Joseph I. Shapiro, Amir Askari, Zijian Xie, Peter Kometiani, Jie Li, and Jiang Liu