Both transcription and splicing take place in a nuclear environment which, at face value, may seem refractory to the efficiency afforded by the coupling of both processes. This environment, chromatin, was once viewed as only a passive packaging system for genetic material, with very little contribution to the variety of nuclear activities occurring within and around it. However, overwhelming evidence now points to the chromatin environment as being highly dynamic, and an active player in nuclear activities.
J. Adam Hall and Philippe T. Georgel (2011). The Worlds of Splicing and Chromatin Collide, RNA Processing, Prof. Paula Grabowski (Ed.), ISBN: 978-953-307-557-0, InTech, Available from: http://www.intechopen.com/books/rna-processing/the-worlds-of-splicing-and-chromatin-collide