Date of Award
2025
Degree Name
Pharmaceutical Sciences
College
School of Pharmacy
Type of Degree
M.S.
Document Type
Thesis
First Advisor
Dr. Michael Hambuchen
Second Advisor
Dr. Cynthia B. Jones
Third Advisor
Dr. Eric R. Blough
Abstract
XYL is becoming more prevalent in opioid intoxication, which not only exacerbates the overdose impact by intensifying the drowsiness and respiratory depression caused by FENT but also increases other toxicities such as cardiovascular and thermoregulatory function. Coexposure to FENT and XYL can have enhanced detrimental effects on human health. In mice, XYL enhances the likelihood of death from FENT exposure. Clinical findings are conflicting as one retrospective study found that patients exposed to both drugs had lower rates of cardiac arrest and coma, but other studies indicate that using XYL together increases the risk of overdose, naloxone administration, and blood levels of Fentanyl. This study examined the effects of α2 antagonist ATI in combination with NLX in reversing XYL-FENT-induced sedation while NLX alone can only partially counteract this effect by targeting on FENT alone. ATI also lessened bradycardia and hyperglycemia, two further consequences of FENT-XYL intoxication and ATI also helped reverse the hypothermia caused by XYL to some extent. This evidence supports the use of the ATI-NLX combination as a safe and effective treatment for FENT and XYL intoxication concurrently.
Subject(s)
Fentanyl.
Xylazine.
Opioids.
Naloxone.
Intoxication.
Recommended Citation
Yalakala, Jyostna, "Naloxone-atipamezole reversal of acute fentanyl-xylazine intoxication in rats" (2025). Theses, Dissertations and Capstones. 1938.
https://mds.marshall.edu/etd/1938
