Fabrication of Nanofiber Scaffolds with Gradations in Fiber Organization and Their Potential Applications
A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially-aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.
Xie, J., Ma, B., Michael, P. L., & Shuler, F. D. (2012). Fabrication of nanofiber scaffolds with gradations in fiber organization and their potential applications. Macromolecular Bioscience, 12(10), 1336-1341. doi: 10.1002/mabi.201200115