Aortic Aging in the Fischer 344 / NNiaHSd × Brown Norway / BiNia Rat

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Aging is now recognized as one of major risk factors for cardiovascular disease (CVD). It is well documented that elderly populations show increased incidence of CVD symptomology but whether these changes are directly related to aging is not well understood since the possibility exists that other age-associated pathologies in different organ systems could impact on cardiovascular function. Hence, the development of an aging model with reduced systemic illness could invigorate efforts to understand the direct role of aging in CVD progression. The Fischer 344 / NNIaHSD × Brown Norway / BiNia rat (F344BN) has been proposed as a potential model for aging that exhibits reduced systemic pathology and increased longevity compared to other models. Here we examine the current literature regarding the F344BN, focusing on age-associated changes in aortic structure and function.


This article first appeared in the December 2008 issue of Journal of Pharmacological Sciences, the member magazine of The Japanese Pharmacological Society, and is reprinted with permission.

©2008 The Japanese Pharmacological Society