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Keywords

lactic acidosis, sodium bicarbonate, carbicarb

Disciplines

Critical Care | Nephrology | Nutritional and Metabolic Diseases | Pharmaceutical Preparations | Therapeutics

Abstract

This report attempts to frame the debate about clinical administration of sodium bicarbonate in the setting of lactic acidosis in terms of simple questions. Specifically, we address why we develop lactic acidosis in some circumstances, how acute lactic acidosis impairs cardiovascular function and why sodium bicarbonate may have deleterious effects which limit its utility. We also attempt to explore treatment alternatives to sodium bicarbonate.

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