A rare case of parasomnia associated with Micronized Progesterone Therapy

Authors

Mouhannad Azzouz, West Virginia UniversityFollow
Anam Sabzwari, West Virginia UniversityFollow
Lee Madruga, West Virginia UniversityFollow
Robert Young, West Virginia UniversityFollow
Matthew O'Neal, West Virginia UniversityFollow

Author Credentials

Lee Madruga, 3rd year medical student Matthew O’Neal, MD Anam Sabzwari, MD Robert Young, DO Mouhannad Azzouz, MD

Keywords

micronized progesterone; parasomnia; sleep disturbances; hormone therapy; endometriosis

Disciplines

Medicine and Health Sciences

Abstract

Micronized progesterone is commonly prescribed to manage hormonal imbalances and gynecological conditions, such as endometriosis. While its sedative effects are well-documented, the occurrence of parasomnias as an adverse effect is rare. This case documents a 48-year-old woman who developed complex parasomnia behaviors shortly after initiating micronized progesterone therapy. The symptoms resolved upon discontinuing the medication, suggesting a probable causal relationship. This case highlights the need for clinicians to be aware of potential sleep-related side effects associated with progesterone therapy.

Recommended Citation

Azzouz M, Sabzwari A, Madruga L, Young R, O'Neal M. A rare case of parasomnia associated with Micronized Progesterone Therapy. Marshall J Med. 2025; 11(2) DOI: https://doi.org/10.33470/2379-9536.1481.