Author Credentials

Natalie A. Moffett, MSIV, Rosemarie Lorenzetti MD, MPH


Lyme disease, Parvovirus B19, Polyarthropathy, Lyme borreliosis screening test, TORCH infections, Appalachia


Bacterial Infections and Mycoses | Family Medicine | Musculoskeletal Diseases | Virus Diseases


This case presentation discusses a 36 year-old female animal care worker presenting with an acute-onset polyarthropathy during the summer months in a Lyme endemic region. Though she appeared to be a good candidate for the diagnosis of Lyme borreliosis, her screening serology reported negative results and alternative diagnoses were considered. Her subsequent diagnosis with parvovirus B19 acts to remind the general practitioner to have confidence in the accuracy of a negative Lyme screen and, upon negative result, to expand the differential to include less common infections including parvovirus B19. It also highlights the need to remember parvovirus B19 in a similar patient who has the potential to be or to become pregnant during the course of her illness.