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The study purpose was to determine if a collaborative educational program would increase the knowledge of prescription drug abuse/misuse in adolescents. This quasi-experimental study consisted of a drug prevention program with a pre and post-test survey for knowledge. The convenience sample included 1,067 middle school/high schools in an Appalachian state. Utilizing a paired t-test, it was determined that the difference between pre and post-test answers was significant with a p-value of 0.006 (95% CI: 7.8%-37.1%) for increase in knowledge. When schools were analyzed separately, all schools experienced a significant increase in knowledge as indicated by the corresponding p-values p<0.05. A collaborative educational program can be an effective way to increase knowledge about prescription drug abuse/misuse in adolescents in Appalachia.


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