Background: Na/K-ATPase decrease has been reported in patients with heart failure and is related to cardiac dysfunction.
Results: Reducing Na/K-ATPase activates caspase 9 and induces cardiac dilation when treated with marinobufagenin.
Conclusion: Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac myocyte apoptosis.
Significance: Decreased Na/K-ATPase content together with increased cardiotonic steroids levels is a novel mechanism that may account for cardiac dysfunction.
Liu C, Y Bai, Y Chen, Y Wang, Y Sottejeau, L Liu, X Li, JB Lingrel, D Malhotra, CJ Cooper, JI Shapero, ZJ Xie, and J Tian. 2012. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem. 287:16390-8.