Document Type


Publication Date

Spring 5-11-2012


Background: Na/K-ATPase decrease has been reported in patients with heart failure and is related to cardiac dysfunction.

Results: Reducing Na/K-ATPase activates caspase 9 and induces cardiac dilation when treated with marinobufagenin.

Conclusion: Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac myocyte apoptosis.

Significance: Decreased Na/K-ATPase content together with increased cardiotonic steroids levels is a novel mechanism that may account for cardiac dysfunction.


The version of record is available from the publisher at This research was originally published in The Journal of Biological Chemistry. Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, et al. Journal of Biological Chemistry. 2012; 287:16390-16398. © The American Society for Biochemistry and Molecular Biology. Reprinted with permission. All rights reserved. DOI 10.1074/jbc.M111.304451