Non-Helicobacter pylori Related Duodenal Ulcer Disease in Children

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In spite of the worldwide distribution of Helicobacter pylori infection, recent data have reported an increased rate of non-H. pylori, non-NSAIDs-duodenal ulcer disease in adults. The estimated rate of these ulcers in children is unknown. We aimed to investigate the prevalence of non-H. pylori, non-NSAIDs-peptic ulcer disease in our pediatric patients who undergo upper endoscopic procedures.


A retrospective analysis of 622 upper endoscopic reports was performed. Reports that documented mucosal ulcerations were included in our study. The demographic, clinical, endoscopic, and histological data were retrieved. The H. pylori-negative, duodenal/gastric ulcer-positive patients were compared with H. pylori-positive, duodenal/gastric ulcer-positive patients.


Out of the 622 upper endoscopy reports, a total of 11 (1.8%) children with mucosal ulceration were studied. Mucosal ulceration was distributed in the following locations: stomach-3 (27%), and duodenal bulb-10 (91%) (two children had ulcers in both the stomach and duodenal bulb). Helicobacter pylori infection was only detected in three (27%) children with duodenal ulcer. Gastritis was more severe in patients with H. pylori infection/duodenal ulcer compared with H. pylori-negative/duodenal ulcer group. No statistical difference in clinical symptoms or endoscopic appearance was observed between the H. pylori-negative and H. pylori-positive groups.


‘Idiopathic’ (H. pylori-negative, NSAIDsnegative) duodenal/gastric ulcers are present in symptomatic children. Clinical or endoscopic characteristics are insufficient markers to identify those ‘idiopathic’ ulcers. Investigating the ‘risk factors’ for those ulcers will be helpful in reducing the morbidity in these children.


This is the pre-peer reviewed version of the following article: Elitsur, Y. and Lawrence, Z. (2001), Non-Helicobacter pylori Related Duodenal Ulcer Disease in Children. Helicobacter, 6: 239–243. doi: 10.1046/j.1523-5378.2001.00034.x, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1046/j.1523-5378.2001.00034.x/abstract

Reprinted with permission.