Hyperammonemia Associated With Valproic Acid Use in Elderly Psychiatric Patients
Valproic acid (VPA) is associated with hyperammonemia; however, little is known about this phenomenon in the geriatric psychiatric population. Of 12 such patients prescribed VPA, 83.3% had elevated ammonia. This occurred in the absence of elevated liver enzymes, and there was no association of VPA serum-level to hyperammonemia.
Holroyd S, Overdyke JT. Hyperammonemia associated with valproic acid use in elderly psychiatric patients. The Journal of Neuropsychiatry and Clinical Neurosciences. 2012 Jul;24(3):372-4.