Title

Antibacterial and cytotoxic activities of the metabolites isolated from a Penicillium strain

Document Type

Article

Publication Date

2003

Abstract

Three antibiotics (RA-1, RA-2 and RA-3) were isolated from the chloroform extract of the fermentation broth of a Penicillium strain of an unidentified species. These compounds exhibited a significant in vitro antibacterial activity against both gram-positive and gram-negative organisms. The MIC values for RA-1, RA-2 and RA-3 were also determined against Bacillus subtilis, Shigella sonnei and Escherichia coli. The chloroform extract also showed strong cytotoxicity in brine shrimp lethality assay.

Comments

Copyright © 2003 Asian Network for Scientific Information. All rights reserved.

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