Antibacterial and cytotoxic activities of the metabolites isolated from a Penicillium strain
Three antibiotics (RA-1, RA-2 and RA-3) were isolated from the chloroform extract of the fermentation broth of a Penicillium strain of an unidentified species. These compounds exhibited a significant in vitro antibacterial activity against both gram-positive and gram-negative organisms. The MIC values for RA-1, RA-2 and RA-3 were also determined against Bacillus subtilis, Shigella sonnei and Escherichia coli. The chloroform extract also showed strong cytotoxicity in brine shrimp lethality assay.
A.R.M. Ruhul Amin, A. Jabbar and M.A. Rashid, 2003. Antibacterial and Cytotoxic Activities of the Metabolites Isolated from a Penicillium Strain. Pakistan Journal of Biological Sciences, 6: 1365-1367.