Pseudomonas aeruginosa MucD Regulates the alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity

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Alginate overproduction in Pseudomonas aeruginosa can be caused by the proteolysis of the anti-sigma factor MucA regulated by the AlgW protease. Here, we show that inactivation of MucD, an HtrA/DegP homolog and alginate regulator, can bypass AlgW, leading to an atypical proteolysis of MucA that is dependent on the MucP protease.


This article was published in Journal of Bacteriology, 2011 January; 193(1): 286–291.

Published online 2010 October 29. doi: 10.1128/JB.01132-10

Publisher: author can archive post-print.