Simplicity and complexity in the cyanobacterial circadian clock mechanism

Authors

Guogang Dong
Yongick Kim, Marshall UniversityFollow
Susan S. Golden

Document Type

Article

Publication Date

12-2010

Abstract

The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.

Comments

This is the authors’ manuscript available from PubMed Central. The version of record is Copyright © 2010 Elsevier Ltd. All rights reserved.

Recommended Citation

Dong G, Kim YI, Golden SS. Simplicity and complexity in the cyanobacterial circadian clock mechanism. Curr Opin Genet Dev. 2010 Dec;20(6):619-25. doi: 10.1016/j.gde.2010.09.002.