Date of Award
College of Science
Type of Degree
John L. Hubbard
Leonard J. Deutsch
N-(3,5-Dichloro-4-fluorophenyl)succinimide (NDCFPS) and N-(3,5-dichloro-4- pyridyl)succinimide (NDPyS) were synthesized using procedures employed previously for N-(3,5-dichIorophenyl)succinimide (NDPS). However, NDPyS was not formed cleanly: extraction from by-products was necessary and purification by column chromatograpy was required. Several potential alternative routes to NDPyS were investigated without success.
Both compounds were administered to male Fischer 344 rats to assess nephrotoxic potential. NDCFPS, contrary to expectations, was non-nephrotoxic. Preliminary results indicate that NDPyS is also non-nephrotoxic.
Noe, Okey II, "Preparation of N-(Haloaryl) succinimides" (1999). Theses, Dissertations and Capstones. 1776.