Date of Award


Degree Name



College of Science

Type of Degree


Document Type


First Advisor

Seth Bush

Second Advisor

William Price

Third Advisor

Lawrence Schmitz


The creatine to creatinine cyclization is of significant biological importance, providing energy for muscle cells and indicating proper renal function. From a chemical perspective, the rate at which creatine cyclizes to form creatinine has interested researchers since the late 1920s, but the cyclization is poorly understood both energetically and mechanistically. Mass spectroscopy was used to determine the rate of creatine cyclization as a function of temperature and pH. Using these values, the energetic parameters, activation energy and Arrhenius factor, were determined as a function of pH to better understand this reaction and ultimately determine the mechanistic process for this reaction. From our experiments, the activation energies and Arrhenius factors for each experimental pH were found to be 83.1 kJ mol -1 and 9.6 at pH 1, 93.6 kJ mol -1 and 11.8 at pH 3, and 79.1 kJ mol -1 and 9.0 at pH 5.



Ring formation (Chemistry)

Mass spectrometry.