Two new species of Compsobuthus from the werneri group are described. C. afghanus sp. n. is characterized chiefly by the combination of numerous rows of granules on the movable finger of pedipalp (14 rows) and a high number of pectinal teeth (29–31). C. pakistanus sp. n. is most similar to C. plutenkoi Kovařík, 2003 from Iran, from which it differs in having internal granules in all rows on the movable finger of pedipalp and 18–19 pectinal teeth. A key is provided for all species of the genus found in Afghanistan, Iran, Pakistan, and adjacent countries.