Document Type

Article

Publication Date

1-2011

Abstract

Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathophysiology of disease. Here we will review some of the recent findings of this field and attempt, where possible, to present changes in mechanotransduction that are associated with the aging process in several selected physiological systems, including musculoskeletal, cardiovascular, neuronal, respiratory systems and skin.

Comments

NOTICE: this is the authors’ version of a work that was accepted for publication in Aging Research Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Aging Research Reviews, [VOL10, ISSUE 1, (2011)] http://dx.doi.org/10.1016/j.arr.2009.11.002

Copyright © 2011 Elsevier B.V. All rights reserved.

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