Document Type
Article
Publication Date
Fall 10-5-2015
Abstract
The severe inflammation observed during sepsis is thought to cause diaphragm dysfunction, which is associated with poor patient prognosis. Cerium oxide (CeO2) nanoparticles have been posited to exhibit anti-inflammatory and antioxidative activities suggesting that these particles may be of potential use for the treatment of inflammatory disorders. To investigate this possibility, Sprague Dawley rats were randomly assigned to the following groups: sham control, CeO2 nanoparticle treatment only (0.5 mg/kg iv), sepsis, and sepsis+CeO2 nanoparticles. Sepsis was induced by the introduction of cecal material (600 mg/kg) directly into the peritoneal cavity. Nanoparticle treatment decreased sepsis-associated impairments in diaphragmatic contractile (Po) function (sham: 25.6±1.6 N/cm2 vs CeO2: 23.4±0.8 N/cm2, vs Sep: 15.9±1.0 N/cm2 vs Sep+CeO2: 20.0±1.0 N/cm2, P2 nanoparticles may improve diaphragmatic function in the septic laboratory rat.
Recommended Citation
Asano S, Arvapalli R, Manne ND, Maheshwari M, Ma B, Rice KM, Selvaraj V, Blough ER. Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction. International Journal of Nanomedicine, 2015;10(1):6215-6226
Comments
The copy of record is available from the publisher at https://doi.org/10.2147/IJN.S89783. Copyright © 2015 The Authors. This article has a Creative Commons License, which permits non-commercial uses of the work without any further permission provided the work is properly attributed.