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Title

Platelet Activation in Patients with Atherosclerotic Renal Artery Stenosis Undergoing Stent RevascularizationPlatelet Activation in Patients with Atherosclerotic Renal Artery Stenosis Undergoing Stent Revascularization

Authors

Steven Haller
Satjit Adlakha
Grant Reed
Pamela Brewster
David Kennedy
Mark W. Burket
William Colyer
Haifeng Yu
Dong Zhang
Joseph I. Shapiro M.D., Marshall UniversityFollow
Christopher J. Cooper

Document Type

Article

Publication Date

Fall 8-4-2011

Abstract

Background and objectives Soluble CD40 ligand (sCD40L) is a marker of platelet activation; whether platelet activation occurs in the setting of renal artery stenosis and stenting is unknown. Additionally, the effect of embolic protection devices and glycoprotein IIb/IIIa inhibitors on platelet activation during renal artery intervention is unknown.

Design, setting, participants, & measurements Plasma levels of sCD40L were measured in healthy controls, patients with atherosclerosis without renal stenosis, and patients with renal artery stenosis before, immediately after, and 24 hours after renal artery stenting.

Results Soluble CD40L levels were higher in renal artery stenosis patients than normal controls (347.5 _ 27.0 versus 65.2 _ 1.4 pg/ml, P _ 0.001), but were similar to patients with atherosclerosis without renal artery stenosis. Platelet-rich emboli were captured in 26% (9 of 35) of embolic protection device patients, and in these patients sCD40L was elevated before the procedure. Embolic protection device use was associated with a nonsignificant increase in sCD40L, whereas sCD40L declined with abciximab after the procedure (324.9 _ 42.5 versus 188.7 _ 31.0 pg/ml, P _ 0.003) and at 24 hours.

Conclusions Atherosclerotic renal artery stenosis is associated with platelet activation, but this appears to be related to atherosclerosis, not renal artery stenosis specifically. Embolization of platelet-rich thrombi is common in renal artery stenting and is inhibited with abciximab.

Comments

This article is available from the American Society of Nephrology at http://cjasn.asnjournals.org/content/early/2011/08/04/CJN.03140411.full.pdf. Copyright © 2011 by the American Society of Nephrology. All rights reserved. DOI: 10.2215/CJN.03140411

Recommended Citation

Haller S, Adlakha S, Reed G, Brewster P, Kennedy D, Burket MW, et al. Platelet activation in patients with atherosclerotic renal artery stenosis undergoing stent revascularization. Clin J Am Soc Nephrol. 2011;6:2185 – 91.