Pseudomonas aeruginosa MucD Regulates the alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity
Alginate overproduction in Pseudomonas aeruginosa can be caused by the proteolysis of the anti-sigma factor MucA regulated by the AlgW protease. Here, we show that inactivation of MucD, an HtrA/DegP homolog and alginate regulator, can bypass AlgW, leading to an atypical proteolysis of MucA that is dependent on the MucP protease.
Damron, F. H., & Yu, H. D. (2011, January). Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity. Journal of Bacteriology, 193(1), 286-291.