Research from 2023
Genome-wide DNA methylation analysis in schizophrenia with tardive dyskinesia: a preliminary study, Chun Xu, Priscila Acevedo, Yongke Lu, Brenda Bin Su, Kaysie Ozuna, Victoria Padilla, Annu Karithara, Chunxiang Mao, R. Osvaldo Navia, Ubolrat Piamjariyakul, and Kesheng Wang
Research from 2021
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase, Xue Chen, Yunhui Xu, Krista L. Denning, Audrey Grigore, and Yongke Lu
Longitudinal analysis of APOE-ε4 genotype with the logical memory delayed recall score in Alzheimer’s disease, Evelyn Fokuoh, Danqing Xiao, Wei Fang, Ying Liu, and Yongke Lu
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1, Yunhui Xu, Krista L. Denning, and Yongke Lu
Research from 2020
Pyrosequencing analysis of IRS1 methylation levels in schizophrenia with tardive dyskinesia, Yanli Li, Kesheng Wang, Ping Zhang, Junchao Huang, Ying Liu, Zhiren Wang, Yongke Lu, Shuping Tan, Fude Yang, and Yunlong Tan
Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities, Steven Tun, Caleb James Spainhower, Cameron Lee Cottrill, Hari Vishal Lakhani, Sneha S. Pillai, Anum Dilip, Hibba Chaudhry, Joseph I. Shapiro, and Komal Sodhi
Research from 2019
Transplanted adult human hepatic stem/progenitor cells prevent histogenesis of advanced hepatic fibrosis in mice induced by carbon tetrachloride, Yanzhen Bi, Xiyu Liu, Chuanping Si, Ye Hong, Yongke Lu, Pengfei Gao, Yonghong Yang, Xiaobei Zhang, Yibo Wang, Huabao Xiong, Zhongping Duan, Yu Chen, and Feng Hong
Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice, Xue Chen, Kesheng Wang, Arthur I. Cederbaum, and Yongke Lu
Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer, Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio, and Candace M. Howard
Research from 2018
Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5, Xue Chen, Emmanuel Owoseni, Julia Salamat, Arthur I. Cederbaum, and Yongke Lu
Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer's Disease, Shaoqing Gong, Brenda Bin Su, Hugo Tovar, ChunXiang Mao, Valeria Gonzalez, Ying Liu, Yongke Lu, Ke-Sheng Wang, and Chun Xu
The Adipokine C1q Tnf Related Protein 3 (CTRP3) Is Elevated in the Breast Milk of Obese Mothers, Megan R. Kwon, Eileen M. Cress, W. Andrew Clark, Arsham Alamian, Yongke Lu, and Jonathan M. Peterson
The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers, Megan R. Kwon, Eileen M. Cress, W. Andrew Clark, Arsham Alamian, Yongke Lu, and Jonathan M. Peterson
Cytochrome P450s and Alcoholic Liver Disease, Yongke Lu and Arthur I. Cederbaum
Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease., Fernando Magdaleno, Xiaodong Ge, Holger Fey, Yongke Lu, Harriet Gaskell, Chuck C. Blajszczak, Costica Aloman, M. Isabel Fiel, and Natalia Nieto
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model, Kesheng Wang, Xue Chen, Stephen C. Ward, Ying Liu, Youssoufou Ouedraogo, Chun Xu, Arthur I. Cederbaum, and Yongke Lu
Research from 2017
Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury, Elena Arriazu, Xiaodong Ge, Tung-Ming Leung, Fernando Magdaleno, Aritz Lopategi, Yongke Lu, Naoto Kitamura, Raquel Urtasun, Neil Theise, Daniel J. Antoine, and Natalia Nieto
Midbrain circuit regulation of individual alcohol drinking behaviors in mice, Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edwards, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, and Ming-Hu Han
Alcoholic Liver Disease: from CYP2E1 to CYP2A5, Tung Ming Leung and Yongke Lu
Research from 2016
Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells, Zhiping He, Allen Y. Chen, Yon Rojanasakul, Gary O. Rankin, and Yi Charlie Chen
The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference, Feng Hong, Chuanping Si, Pengfei Gao, Arthur I. Cederbaum, Huabao Xiong, and Yongke Lu
Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species, Yongke Lu and Arthur I. Cederbaum
Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells, Youying Tu, Eunhye Kim, Ying Gao, Gary O. Rankin, Bo Li, and Yi Charlie Chen
Research from 2015
Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury, Arthur I. Cederbaum, Yongke Lu, Xiaodong Wang, and Defeng Wu
Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice, Feng Hong, Xiyu Liu, Stephen S. Ward, Huabao Xiong, Arthur I. Cederbaum, and Yongke Lu
Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway, Haizhi Huang, Allen Y. Chen, Xingqian Ye, Bingyun Li, Yon Rojanasakul, Gary O. Rankin, and Yi Charlie Chen
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity, Yongke Lu and Arthur I. Cederbaum
Research from 2014
High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD), Xiaodong Ge, Daniel J. Antoine, Yongke Lu, Elena Arriazu, Tung-Ming Leung, Arielle L. Klepper, Andrea D. Branch, Maria Isabel Fiel, and Natalia Nieto
Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice, Xiaodong Ge, Tung‐Ming Leung, Elena Arriazu, Yongke Lu, Raquel Urtasun, Brian Christensen, Maria Isabel Fiel, Satoshi Mochida, Esben S. Sørensen, and Natalia Nieto
Ethanol Plus the Jo2 Fas Agonistic Antibody‐Induced Liver Injury is Attenuated in Mice with Partial Ablation of Argininosuccinate Synthase, Yongke Lu, Stephen C. Ward, and Natalia Nieto
Osteopontin induces ductular reaction contributing to liver fibrosis, Xiaodong Wang, Aritz Lopategi, Xiaodong Ge, Yongke Lu, Naoto Kitamura, Raquel Urtasun, Tung-Ming Leung, Maria Isabel Fiel, and Natalia Nieto
Research from 2013
Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury, Xiaodong Ge, Yongke Lu, Tung-Ming Leung, Esben S. Sørensen, and Natalia Nieto
Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse live, Yongke Lu, Stephen Ward, and Arthur I. Cederbaum
Research from 2012
Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis, Almudena Bosch, Silvina P. Bertran, Yongke Lu, Avalon Garcia, Alexis M. Jones, Marcia I. Dawson, and Eduardo F. Farias
Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice, Tung Ming Leung, Yongke Lu, Wei Yan, José A. Morón‐Concepción, Stephen C. Ward, Xiaodong Ge, Laura Conde de la Rosa, and Natalia Nieto
Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress, Yongke Lu, Tung Ming Leung, Stephen C. Ward, and Natalia Nieto
Ethanol Induction of CYP2A5: Role of CYP2E1-ROS-Nrf2 Pathway, Yongke Lu, Xu Hannah Zhang, and Arthur I. Cederbaum
Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice, Elisabetta Mormone, Yongke Lu, Xiaodong Ge, Maria Isabel Fiel, and Natalia Nieto
Research from 2011
Ethanol Induction of CYP2A5: Permissive Role for CYP2E1, Yongke Lu, Jian Zhuge, Defeng Wu, and Arthur I. Cederbaum
Research from 2010
CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction, Yongke Lu and Arthur I. Cederbaum
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice, Yongke Lu, Defeng Wu, Xiaodong Wang, Stephen C. Ward, and Arthur I. Cederbaum
Research from 2009
Role of oxidative stress in alcohol-induced liver injury, Arthur I. Cederbaum, Yongke Lu, and Defeng Wu
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase, Xiaodong Wang, Yongke Lu, Bin Xie, and Arthur I. Cederbaum
Research from 2008
CYP2E1 and oxidative liver injury by alcohol, Yongke Lu and Arthur I. Cederbaum
Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency, Yongke Lu, Pengfei Gong, and Arthur I. Cederbaum
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice, Yongke Lu, Jian Zhuge, Xiaodong Wang, Jingxiang Bai, and Arthur I. Cederbaum
Research from 2007
The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin, Yongke Lu and Arthur Cederbaum
Research from 2006
Cisplatin-Induced Hepatotoxicity Is Enhanced by Elevated Expression of Cytochrome P450 2E1, Yongke Lu and Arthur I. Cederbaum
Enhancement by pyrazole of lipopolysaccharide‐induced liver injury in mice: Role of cytochrome P450 2E1 and 2A5, Yongke Lu and Arthur I. Cederbaum
Research from 2005
Cisplatin-Induced Cytotoxicity in BSO-Exposed Renal Proximal Tubular Epithelial Cells: Sex, Age, and Species, Yongke Lu, Akira Kawashima, Ikuo Horii, and Laifu Zhong
Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole, Yongke Lu, Xiaodong Wang, and Arthur I. Cederbaum
Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice, Xiaodong Wang, Yongke Lu, and Arthur I. Cederbaum
