Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines
Document Type
Article
Publication Date
Spring 3-2009
Abstract
The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 μM) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.
Recommended Citation
Musa MA, F Khan MO, Cooperwood JS. Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines. Letters in Drug Design & Discovery. 2009 Mar 1;6(2):133-8.
COinS
Comments
The is the peer-reviewed authors’ manuscript. The version of record is available from the publisher at http://dx.doi.org/10.2174/157018009787582624. Copyright © 2009 Bentham Science Publishers Ltd. All rights reserved.