Date of Award
2019
Degree Name
Chemistry
College
College of Science
Type of Degree
M.S.
Document Type
Thesis
First Advisor
Dr. Michael Castellani
Second Advisor
Dr. Robert Morgan
Third Advisor
Dr. John Markiewicz
Abstract
Although isoelectronic to benzene, the reactivity of pyridine-derived compounds can be quite different. Notably, routes to prepare pyridyl analogs to known phenyl compounds can be very different from how the phenyl compounds are made, even when the nitrogen atom would appear to play an insignificant role in the reaction. This is the case for 1,3-di-4-pyridylacetone. Its phenyl analog has been known for over 90 years and is easily prepared, while the only reported synthesis of 1,3-di-4-pyridylacetone occurs in very low yield. We report a preliminary synthesis from common starting materials, albeit in low yield, and offer an explanation for why previous preparations were unsuccessful and how yields could be improved.
Subject(s)
Phenyl compounds.
Recommended Citation
Boggs, Zachary Tyler, "Synthesis of 1,3-DI(4-Pyridinyl)Acetone" (2019). Theses, Dissertations and Capstones. 1216.
https://mds.marshall.edu/etd/1216
