Evaluation of the physical properties and in vitro safety of chitosan-Quercus infectoria topical gel
Date of Award
2026
Degree Name
Pharmaceutical Sciences
College
School of Pharmacy
Type of Degree
M.S.
Document Type
Thesis
First Advisor
Dr. Cynthia Jones
Second Advisor
Dr. Hasan Koc
Third Advisor
Dr. Emine C. Koc
Abstract
Due to ongoing inflammation, inadequate blood flow, oxidative stress, and reduced tissue regeneration, chronic diabetic wounds heal slowly, which is a serious health concern. It is important to examine novel strategies that tackle these issues because conventional treatments frequently fail. Therefore, this study examined the physical properties and biocompatibility of a novel topical gel formulated with chitosan and Quercus infectoria gall extract.
Over 28 days, pH, spreadability, texture, homogeneity, color, and drug concentration were assessed. UV-visible spectrophotometry and FTIR analysis were used to establish chemical stability. The MTT assay was used to test its safety in human dermal fibroblast adult (HDFa) cells, and each sample was treated for 24, 48, and 72 hours.
Our findings demonstrate that the gel is biocompatible with HDFa cells and remained stable during the study period. The combination of Quercus infectoria antioxidant, antiinflammatory, and antibacterial qualities with chitosan biocompatibility and ability to promote wound healing suggests that this formulation could improve diabetic wound healing in a synergistic way. These results lay the groundwork for further preclinical and clinical research and demonstrate the potential of integrating natural bioactive chemicals with biopolymers as a safe and efficient method of treating chronic wounds.
Subject(s)
Pharmaceutical chemistry.
Drugs -- Research.
Diabetes.
Wound healing.
Colloids.
Gels (Pharmacy)
Aleppo oak.
Cells.
Biopolymers.
Chemicals.
Chitosan
Recommended Citation
Tillapudi, Rani Naga Rakshitha, "Evaluation of the physical properties and in vitro safety of chitosan-Quercus infectoria topical gel" (2026). Theses, Dissertations and Capstones. 2055.
https://mds.marshall.edu/etd/2055
