Date of Award
2026
Degree Name
Pharmaceutical Sciences
College
School of Pharmacy
Type of Degree
M.S.
Document Type
Thesis
First Advisor
Dr. Cynthia Jones
Second Advisor
Dr. Michael Hambuchen
Third Advisor
Dr. Timothy Long
Abstract
Non-Alcoholic Fatty Liver Disease (NAFLD) is a progressive metabolic disorder characterized by excessive lipid accumulation in hepatocytes and chronic inflammation. Nanoparticle-based drug delivery systems offer a promising strategy to enhance therapeutic efficacy while minimizing systemic toxicity. The objective of this study is to formulate and characterize 5-FU–loaded PLGA nanoparticles and evaluate their in vitro performance. 5-FU–loaded PLGA nanoparticles were prepared using the double emulsion solvent evaporation method. The nanoparticles were characterized by particle size, polydispersity index, zeta potential and SEM. Drug encapsulation efficiency, loading capacity and in vitro drug release studies were conducted. The formulated nanoparticles exhibited sizes within the nanoscale range with irregular morphology and successful incorporation of 5-FU within the PLGA matrix. The successful formulation and characterization of 5-FU–loaded PLGA nanoparticles highlight their potential as a controlled drug delivery system. These findings provide a foundation for future studies involving biological evaluation and targeted therapeutic applications.
Subject(s)
Pharmaceutical chemistry.
Drugs -- Research.
Wound healing.
Nanoparticles.
Wounds and injuries -- Treatment.
Drug delivery systems.
Fluorouracil.
Liver -- Diseases.
Recommended Citation
Yandapalli, Kavya, "Development and in vitro characterization of 5-Fluorouracil–loaded PLGA nanoparticles for controlled drug delivery" (2026). Theses, Dissertations and Capstones. 2059.
https://mds.marshall.edu/etd/2059
