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Author Credentials

Kyle Admire, DO Charlotta Jornlid, DO Chelsea Ryan, MD Rebecca Pauly, MD, FACP

Author ORCID Identifier

Kyle Admire, DO - ORCID ID: 0000-0002-2231-3564

Charlotta Jornlid, DO - ORCID ID: 0000-0002-2892-1106

Chelsea Ryan, MD - ORCID ID: 0000-0002-2872-1972

Rebecca Pauly, MD, FACP - N/A

Keywords

nephrotic syndrome, occlusive myocardial infarction, diabetes, thrombosis

Disciplines

Cardiology | Medicine and Health Sciences | Nephrology

Abstract

Nephrotic syndrome is a rare condition distinguished by proteinuria exceeding 3g per day. Other associated characteristics include hematuria, hypoalbuminemia, edema, and hyperlipidemia. There is an array of complications of this syndrome, which are primarily due to the profound losses of protein in the urine. One such complication is thromboembolism, with most documented cases in the form of venous thromboembolism of the extremities which is in part due to urinary loss of antithrombin III and increased synthesis of prothrombotic factors. There are limited available data regarding arterial thrombi and especially few reports about coronary thromboses, which can be life-threatening. In this report, we present the case of a 26-year-old patient with known nephrotic syndrome who developed an occlusive myocardial infarction from coronary artery thrombosis after a delay in care. We discuss the need for prompt diagnosis and treatment of nephrotic syndrome. Additionally, we review the differences between primary and secondary etiologies as well as their management.

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