Author Credentials

Colton Kinderknecht, OMS-III Kevin Mathews, OMS-III Elizabeth Kane, M.D.

Author ORCID Identifier



Quetiapine, Agitation, Aggression


Medicine and Health Sciences | Other Psychiatry and Psychology


Quetiapine is an atypical antipsychotic that is used in many clinical scenarios; it has been approved and has shown to be effective in the treatment of schizophrenia and bipolar symptoms. Additionally, it has several off-label uses including the treatment of insomnia. In this case report, an elderly veteran was given quetiapine as a sleep aid. After the first dose, he demonstrated severe agitation. To the best of our knowledge, there have been limited reports of this reaction. Although there are limitations to this case report, it serves as a cautionary lesson when prescribing a medication like quetiapine and to consider alternatives when available.