Author ORCID Identifier
0000-0001-8195-6036
Keywords
glymphatic, sleep, neurodegenerative diseases, cerebrospinal fluid
Disciplines
Circulatory and Respiratory Physiology | Medicine and Health Sciences
Grant Award Number
DG is supported in part by NIH grants HL166617, HL169266 and P20GM103434 to the West Virginia IDeA Network of Biomedical Research Excellence.
Abstract
It has been less than 15 years since the glymphatic system was identified. The discovery has revolutionized the understanding of the unique functions of cerebrospinal fluid (CSF) and the extracellular fluid within the central nervous system (CNS) and their unique connectivity to the rest of the body. The role of sleep in regulating glymphatic clearance from the brain and the potential reciprocal role of the glymphatic system in modulating regional neuronal activities, including sleep states, is rapidly emerging. It is shedding light on the role of sleep and the glymphatic system as toxic waste clearance facilitators for the brain, revealing their synergistic roles in preserving cognitive function and their protective activity in the context of neurodegenerative diseases and aging.
Recommended Citation
Gozal D.
The glymphatic system and sleep: functional relevance for brain homeostasis and beyond.
Marshall J Med.
2025;
11(3)
DOI: https://doi.org/10.33470/2379-9536.1493.
