Author Credentials

Justin Chuang, MSIV, Sona Shah, MD


HSV2, periodic lateralized epileptiform discharges, PLEDS, HSV 2 PLEDS, Herpes simplex virus type 2 PLEDS, PLEDS HSV, HSV-2 encephalitis PLEDS


Nervous System Diseases


Herpes Simplex Encephalitis has been found to be one of the most common causes of fatal viral encephalitis (1). The mortality rate in untreated patients has been found to be as high as 70%, thus, correct management and early diagnosis are important for good prognoses and crucial for predicting outcomes. (1,2) In patients with Herpes Simplex Virus (HSV), specific findings such as the Periodic lateralized epileptic form discharges (PLEDs) are considered a specific finding on electroencephalogram (EEG). PLEDs are usually seen in the context of destructive structural lesions involving the cortex. Other causes may include acute ischemic stroke and, less commonly, tumors. This finding of PLEDs has been linked to epileptic seizures, including status epilepticus.(3)

We report a case of HSV type 2 infection and PLEDs as it is not a common presentation, unlike HSV type 1 infection.