Author Credentials

Badar Hasan, MD, Talal Asif, MD, Maryam Hasan, MD, Amr Edrees, MD


Systemic Lupus Erythematous, Catastrophic Antiphospholipid Syndrome, Diffuse Alveolar Hemorrhage


Critical Care | Internal Medicine | Rheumatology


Systemic Lupus Erythematous(SLE) is a multisystem autoimmune disease. It has been identified as the underlying cause for death for an average 1,034 deaths from 2000 and 2014. Our cases highlight two rare but life threatening complications of SLE; Catastrophic antiphospholipid syndrome (CAPS) and Diffuse alveolar hemorrhage (DAH) with mortality as high as 50-90%. Both cases presenting with respiratory symptoms, required meticulous monitoring in ICU and initially treated with broad spectrum antibiotics However, unlike pneumonia these patients required immunosuppressive and plasmapheresis leading to clinical improvement.