Diabetic muscle infarction (DMI) is a rare microvascular complication of spontaneous ischemic necrosis of skeletal muscle in patients with poorly controlled diabetes. We herein describe the case of a 26-year-old woman with a history of type I diabetes and accompanying diabetic microvascular complications of neuropathy, nephropathy and retinopathy, who presented with sudden onset of swelling and sharp pain in her bilateral thighs. T2-weighted MRI imaging revealed subcutaneous edema and sub-fascial, hyper-intense enhancement of proximal thigh musculature. DMI has a relatively non-specific clinical presentation; therefore, physician awareness is key for early diagnosis, as aggressive management has been associated with poor patient outcomes. With poor long-term prognosis and high reoccurrence, DMI acts as an indicator of vascular end-organ damage.
Conflict(s) of Interest
The authors have no financial disclosures to declare and no conflicts of interest to report.
Seaman, Callie; Amos, Michael; Franks, Adam M.; Sexton, Asher; McClelland, Kimberly; and Harris, Erika M.
"Diabetic Muscle Infarction: A Rare End-Organ Vascular Complication of Diabetes,"
Marshall Journal of Medicine:
4, Article 6.
Available at: https://mds.marshall.edu/mjm/vol5/iss4/6