Arthritis Post-Immunotherapy for Endometrial Cancer: a case report and review of literature on the acute onset of inflammatory arthritis following PD-I inhibitor therapy in a patient with recurrent endometrial cancer

Authors

Sydney Graham, Marshall University Joan C. Edwards School of MedicineFollow
Emily Sloane, Marshall University Joan C. Edwards School of MedicineFollow
Nadim Bou Zgheib, Marshall University Joan C. Edwards School of MedicineFollow

Author Credentials

Sydney Graham, MPH Emily Sloane, M.D. Nadim Bou Zgheib, M.D.

Keywords

pembrolizumab, immunotherapy, immune-related adverse event, inflammatory arthritis, endometrial cancer, arthralgia

Disciplines

Medicine and Health Sciences

Abstract

Since gaining FDA approval in 2014, pembrolizumab, a PD-1 immune checkpoint inhibitor, has been utilized in the management of cancers that progress following first-line therapy.While the pathological response to pembrolizumab is favorable, immune related adverse events (irAEs) can be elicited and require prompt diagnosis and management based on grading and severity, which can include discontinuation of immunotherapy.Our case concerns a 66-year-old female with recurrent endometrial cancer who was treated with pembrolizumab, and developed inflammatory arthritis following therapy. We provide a succinct review of the pathogenesis and risk factors associated with irAEs, as well as diagnosis and management strategies.

Recommended Citation

Graham S, Sloane E, Bou Zgheib N. Arthritis Post-Immunotherapy for Endometrial Cancer: a case report and review of literature on the acute onset of inflammatory arthritis following PD-I inhibitor therapy in a patient with recurrent endometrial cancer. Marshall J Med. 2021; 7(2): 21 DOI: https://doi.org/10.33470/2379-9536.1326.