Author Credentials

Samantha A. Smith, MD Adam M. Franks, MD William Rollyson, MD Doreen Griswold, MD Tammy Bannister, MD

Author ORCID Identifier

Adam M. Franks, MD (ORCID# 0000-0002-3710-6138)


Pulmonary, Langerhans Cell Histiocytosis, Osseous, Tobacco Abuse


Immune System Diseases | Medicine and Health Sciences | Oncology | Orthopedics | Pulmonology | Respiratory Tract Diseases


Langerhans cells are dendritic cells that form the antigenic barrier of the human body. They occur in nearly any tissue but are most prevalent in the skin, submucosa of the bronchial tree, and other mucosae. Langerhans Cell Histiocytosis (LCH) develops when these cells damage the tissues in which they reside through a combination of inflammatory and monoclonal stimulation. The pulmonary variant of LCH involves the lung parenchyma and creates a wide variety of disturbances: pulmonary hypertension and both obstructive and restrictive lung disease. Osseous involvement, in addition to the pulmonary variant, presents with pulmonary masses and lytic bone lesions, which sparks suspicion for malignancy. Early recognition of this rare pathology is important as early treatment is clinically beneficial. The following explores a case of adult Pulmonary Langerhans Cell Histiocytosis with osseous involvement.