Propofol Related Infusion Syndrome: A Subtle Adversary

Authors

Brandon Harris, Marshall UniversityFollow
Elizabeth C. Taylor, Cabell Huntington HospitalFollow
John W. Pickstone, Marshall UniversityFollow
Errington C. Thompson MD, Marshall UniversityFollow

Author Credentials

Brandon Harris, MD Elizabeth C. Taylor, PharmD, BCCCP John W. Pickstone, BS Errington C. Thompson, MD, FACS, FCCM

Author ORCID Identifier

0000-0003-4192-7606

Keywords

Propofol, Propofol Related Infusion Syndrome, metabolic acidosis, rhabdomyolysis, PRIS

Disciplines

Medicine and Health Sciences

Abstract

Propofol Related Infusion Syndrome (PRIS) was first described in 1998. It has a strange collection of symptoms, including marked bradycardia, persistent, recalcitrant metabolic acidosis, liver enlargement, rhabdomyolysis, and lipemic blood. We present two recent patients who appeared to have had PRIS. Creatinine kinase seems to be an early detector of PRIS. If PRIS is recognized early, this complex metabolic process seems to be completely reversible.

Recommended Citation

Harris B, Taylor EC, Pickstone JW, Thompson EC. Propofol Related Infusion Syndrome: A Subtle Adversary. Marshall J Med. 2023; 9(1) DOI: https://doi.org/10.33470/2379-9536.1378.