In vitro characterization of SynthoPlateTM (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice

Document Type

Article

Publication Date

2-2017

Abstract

Background: Platelet transfusion applications face severe challenges, owing to the limited availability and portability, high risk of contamination and short shelf-life of platelets. Therefore, there is significant interest in synthetic platelet substitutes that can provide hemostasis while avoiding these issues. Platelets promote hemostasis by injury site-selective adhesion and aggregation, and propagation of coagulation reactions on their membranes. On the basis of these mechanisms, we have developed a synthetic platelet technology (SynthoPlateTM) that integrates platelet-mimetic site-selective ‘adhesion’ and ‘aggregation’ functionalities via eteromultivalent surface decoration of lipid vesicles with von Willebrand factor-binding, collagen-binding and active platelet integrin glycoprotein (GP) IIb–IIIa-binding peptides.

Comments

Copyright © 2016 International Society on Thrombosis and Haemostasis. All rights reserved.

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