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Research from 2009

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Effects of Alternating Current Frequency and Permeation Enhancers Upon Human Epidermal Membrane, Qingfang Xu, Rajan P. Kochambilli, Yang Song, Jinsong Hao, William I. Higuchi, and S. Kevin Li

Research from 2008

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Use of multiple fluorophores for evaluating microvascular permeability in control and septic rats, Ragheb A. Assaly, Robert H. Habib, Mustafa Azizi, Joseph I. Shapiro MD, and David Dignam

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Regulation of Apical NHE3 Trafficking by Ouabain-Induced Activation of Basolateral Na/K-ATPase Receptor Complex, Haiping Cai, Liang Wu, Weikai Qu, Deepak Malhotra, Zijian Xie, Joseph I. Shapiro, and Jiang Liu

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Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress, Jian Cao, George Drummond, Kazuyoshi Inoue, Komal Sodhi, Xiao Ying Li, and Shinji Omura

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Embolic Protection and Platelet Inhibition During Renal Artery Stenting, Christopher J. Cooper MD, Steven T. Haller MS, William Colyer MD, Michael Steffes MD, Mark W. Burket MD, William J. Thomas MD, Robert Safian MD, Bhagat Reddy MD, Pamela Brewster MA, Mary Ann Ankenbrandt MD, Renu Vermani MD, Eric Dippel MD, Krishna Rocha-Singh MD, Timothy P. Murphy MD, David J. Kennedy PhD, Joseph I. Shapiro MD, Ralph D. D'Agostino PhD, Michael J. Pencina PhD, and Sadik Khuder PhD

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Mechanistic Study of Electroosmotic Transport Across Hydrated Nail Plates: Effects of pH and Ionic Strength, Jinsong Hao and S. Kevin Li

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Transungual Iontophoretic Transport of Polar Neutral and Positively Charged Model Permeants: Effects of Electrophoresis and Electroosmosis, Jinsong Hao and S. Kevin Li

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Chemical Method to Enhance Transungual Transport and Iontophoresis Efficiency, Jinsong Hao, Kelly A. Smith, and S. Kevin Li

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DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation, Kedar Hastak, Rajib K. Paul, Mukesh K. Agarwal, Vijay S. Thakur, Arm R. Amin, Sudesh Agrawal, R. Michael Sramkoski, James W. Jacobberger, Mark W. Jackson, George R. Stark, and Munna L. Agarwal

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Synthesis and Pharmacology of Anti-inflammatory Steroidal Antedrugs, M. O. Faruk Khan and Henry J. Lee

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A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer, Musiliyu A. Musa, John S. Cooperwood, and M. Omar Faruk Khan

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Welcoming β-catenin to the gonadotropin-releasing hormone transcriptional network in gonadotropes, Travis Salisbury, April K. Binder, and John H. Nilson

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Silicone Elastomer Uptake Method for Determination of Free 1-Alkyl-2-Pyrrolidone Concentration in Micelle and Hydroxypropyl-b-Cyclodextrin Systems Used in Skin Transport Studies, Kevin S. Warner, Dalia S. Shaker, Sarah Molokhia, Qingfang Xu, Jinsong Hao, William I. Higuchi, and S. Kevin Li

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Alternating Current (AC) Iontophoretic Transport across Human Epidermal Membrane: Effects of AC Frequency and Amplitude, Guang Yan, Qingfang Xu, Yuri G. Anissimov, Jinsong Hao, William I. Higuchi, and S. Kevin Li

Research from 2007

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DNA replication licensing factor (MCM5) rescues p53-mediated growth arrest, Mukesh K. Agarwal, Arm R. Amin, and Munna L. Agarwal

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A role for SHPS-1/SIRPα in concanavalin A-dependent production of MMP-9, Arm R. Amin, M. Helal Uddin Biswas, Takeshi Senga, Gen-Sheng Feng, Reiji Kannagi, Munna L. Agarwal, and Michinari Hamaguchi

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A Novel Role for p73 in the Regulation of Akt-Foxo1a-Bim Signaling and Apoptosis Induced by the Plant Lectin, Concanavalin A, Arm R. Amin, Rajib K. Paul, Vijay S. Thakur, and Munna L. Agarwal

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SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53-target genes induced by the green tea polyphenol EGCG, Arm R. Amin, Vijay S. Thakur, Rajib K. Paul, Gen Sheng Feng, Cheng-Kui Qu, Hasan Muktar, and Munna L. Agarwal

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Partial nephrectomy as a model for uremic cardiomyopathy in the mouse, David J. Kennedy, Jihad Elkareh, Amjad Shidyak, Anna P. Shapiro, Sleiman Smaili, Krishna Mutgi, Shalini Gupta, Jiang Tian, Eric Morgan, Samer Khouri, Christopher J. Cooper, Sankaridrug M. Periyasamy, Zijian Xie, Deepak Malhorta, Olga V. Fedorova, Alexei Y. Bagrov, and Joseph I. Shapiro MD

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Trypanothione Reductase: A Viable Chemotherapeutic Target for Antitrypanosomal and Antileishmanial Drug Design, M. O. Faruk Khan

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Effect of Standard Treatment Guidelines with or without Prescription Audit on Prescribing for Acute Respiratory Tract Infection (ARI) and Diarrhoea in some Thana Health Complexes (THCs) of Bangladesh, M. O. Faruk Khan, A.K. Azad Chowdhury, M. A. Matin, K. Begum, and M. A. Galib

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Maximal activity of the luteinizing hormone β-subunit gene requires β-catenin, Travis Salisbury, April K. Binder, Jean C. Grammer, and John H. Nilson

Research from 2005

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Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy, David J. Kennedy, Sandeep Vetteth, Sankaridrug M. Periyasamy, Mohamed Kanj, Larisa Fedorova, Samer Khouri, M. Bashar Kahaleh, Zijian Xie, Deepak Malhotra, Nikolai I. Kolodkin, Edward G. Lakatta, Olga V. Fedorova, Alexei Y. Bagrov, and Joseph I. Shapiro MD

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GRP78/BIP is Involved in Ouabain-Induced Endocytosis of the Na/K-ATPase in LLC-PK1 Cells, Riad Kesiry and Jiang Liu

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Ouabain-induced Endocytosis and Signal Transduction of the Na/K-ATPase, Jiang Liu

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Ouabain-induced Endocytosis of the Plasmalemmal Na/K-ATPase in LLC-PK1 Cells Requires Caveolin-1, Jiang Liu, Man Liang, Lijun Liu, Deepak Malhotra, Zijian Xie, and Joseph I. Shapiro

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Cardiac Glycoside Downregulates NHE3 Activity and Expression in LLC-PK1 Cells, Shadi Oweis, Liang Wu, Pawel R. Kiela, Deepak Malhotra, Fayez K. Ghishan, Zijian Xie, Joseph I. Shapiro, and Jiang Liu

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Antitrypanosomal, Antileishmanial, and Antimalarial Activities of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, a New Class of Trypanothione Reductase Inhibitor, and of N-Acyl Derivatives of 2-Amino-4-Chlorophenyl Phenyl Sulfide, Seheli Parveen, M. O. Faruk Khan, Susan E. Austin, Simon L. Croft, Vanessa Yardley, Peter Rock, and Kenneth T. Douglas

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Salt Loading Induces Redistribution of the Plasmalemmal Na/K-ATPase in Proximal Tubule Cells, Sankaridrug M. Periyasamy, Jiang Liu, Feras Tanta, BEsher Kabak, Brent Wakefield, Deepak Malhorta, David j. Kennedy, Alaa Nodoor, Olga V. Fedorova, William Gunning, Zijian Xie, Alexi Y. Bagrov, and Joseph I. Shapiro

Research from 2004

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Mechanisms for Aldosterone and Spironolactone-Induced Positive Inotropic Actions in the Rat Heart, John C. Barbato, Sumia Rashid, Patrick J. Mulrow, Joseph I. Shapiro MD, and Roberto Franco-Saenz

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Probing Proteinase Active Sites Using Oriented Peptide Mixture Libraries – ADAM-10, John L. Krstenansky, Jihong Wang, Gregg R. Chenail, Matthew R. Tiffany, Geoffrey M. Kuesters, Barbara C. Natke, and John L. Nestor Jr.

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Ouabain Induces Endocytosis of Plasmalemmal Na/K-ATPase in LLC-PK1 Cells by a Clathrin-dependent Mechanism, Jiang Liu, Riad Kesiry, Sankaridrug M. Periyasamy, Deppak Malhorta, Zijian Xie, and Joseph I. Shapiro

Research from 2002

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A role for SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling, Arm R. Amin, Kazuya Machida, Kumi Oshima, Myat Lin Oa, Aye Aye Thant, Takeshi Senga, Satoru Matsuda, Anwarul Azim Akhand, Akito Maeda, Tomohiro Kurosaki, and Michinari Hamaguchi

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Effects of Cardiac Glycosides on Sodium Pump Expression and Function in LLC-PK1 and MDCK Cells, Jiang Liu, Sankaridrug M. Periyasamy, William Gunning, Olga V. Fedorova, Alexi Y. Bagrov, Deepak Malhorta, Zijian Xie, and Joseph I. Shapiro

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A Study of 5-aminolevulinic Acid and its Methyl Ester Used in In vitro and In vivo Systems of Human Bladder Cancer, Vanaja Manivasager, Paul Wan Sia Heng, Jinsong Hao, Wei Zheng, Khee Chee Soo, and Malini Olivo

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Macro-microscopic Fluorescence Imaging of Human NPC Xenografts in a Murine Model Using Topical vs. Intravenous Administration of 5-Aminolevulinic Acid, Vanaja Manivasager, Paul Wan Sia Heng, Jinsong Hao, Wei Zheng, Khee Chee Soo, and Malini Olivo

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Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat, Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga V. Fedorova, Alexei Y . Bagrov, Jiang Liu, Sankaridrug M. Periyasamy, David Kennedy, Deepak Malhorta, Zijian Xie, and Joseph I. Shapiro MD

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In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats, Travis Salisbury and Jennifer L. Marcinkiewicz

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Formulation of Insulin-loaded Chitosan Nanoparticles: Influence of Factors on Entrapment Efficiency, Pan Yan, Li Yingjian, Zhao Huiying, Jinsong Hao, and Zheng Junmin

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Pharmacokinetics and Local Tissue Disposition of Piroxicam Following Topical and Oral Application in Rats, Li Yingjian, Pan Yan, Xu Hui, Wei Gang, Jinsong Hao, and Zheng Junmin

Research from 2001

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Initial Evidence of Endothelial Cell Apoptosis as a Mechanism of Systemic Capillary Leak Syndrome, Ragheb Assaly MD; Dan Olson MD, PhD, FCCP; Jeffrey Hammersley MD, FCCP; Pan-Sheng Fan MD; Jiang Liu PhD; Joseph I. Shapiro MD; and M. Bashar Kahaleh MD

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Rapid Effects of Aldosterone and Spironolactone in the Isolated Working Rat Heart, John C. Barbato, Patrick J. Mulrow, Joseph I. Shapiro MD, and Roberto Franco-Saenz

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In vitro Antibacterial Screening of the Metabolite of a Monocillium Species Isolated from a Soil Sample of Bangladesh, M. Helal Uddin Biswas, Arm R. Amin, Shah Alam Bhuiyan, M. A. Rashid, M. Ahmed, and M. A. Islam

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Effects of enhanced oxygen release from hemoglobin by RSR13 in an acute renal failure model, Thomas J. Burke, Deepak Malhorta, and Joseph I. Shapiro MD

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Cardiac performance in inbred rat genetic models of low and high running capacity, J. Chen, G. M. Feller, J. C. Barbato, S. Periyasamy, Zijian Xie, L. G. Koch, Joseph I. Shapiro MD, and S. L. Britton

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Effect of Chronic Renal Failure on Cardiac Contractile Function, Calcium Cycling, and Gene Expression of Proteins Important for Calcium Homeostasis in the Rat, David Keenedy, Eiad Omran, Sankaridrug M. Periyasamy, Jalaa Nadoor, Anumeet Priyadarshi, James C. Wiley, Deepak Malhotra, Jingwei Xie, and Joseph I. Shapiro MD

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Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function, Sankaridrug M. Periyasamy, Jie Chen, Derek Cooney, Patricia Carter, Eiad Omran, Jiang Tian, Snigdha Priyadarshi, Alexei Bagrov, Olga Fedorova, Deepak Malhotra, Zijian Xie, and Joseph I. Shapiro MD

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Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat, Anumeet Priyadarshi, Sankaridrug Periyasamy, Thomas J. Burke, Steven L. Britton, Deepak Malhorta, and Joseph I. Shapiro MD

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Effect of Experimental Parameters on the Encapsulation of Insulin-loaded Poly(lactide-co-glycolide) Nanoparticles Prepared by a Double Emulsion Method, Pan Yan, Zhao Huiying, Xu Hui, Wei Gang, Jinsong Hao, and Zheng Junming

Research from 2000

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Use of an Additional Hydrophobic Binding Site, the Z Site, in the Rational Drug Design of a New Class of Stronger Trypanothione Reductase Inhibitor, Quaternary Alkylammonium Phenothiazines, M. O. Faruk Khan, Susan E. Austin, Cecil Chan, Hong Yin, Debora Marks, Sheetal N. Vaghjiani, Howard Kendrick, Vanessa Yardley, Simon L. Croft, and Kenneth T. Douglas

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Ouabain Interaction with Cardiac Na+/K+-ATPase Initiates Signal Cascades Independent of Changes in Intracellular Na+ and Ca2+, Jiang Liu, Jiang Tian, Michael Haas, Joseph I. Shapiro, Amir Askari, and Zijian Xie

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A role for FAK in the Concanavalin A-dependent secretion of matrix metalloproteinase-2 and -9, Thet Thet Sein, Aye Aye Thant, Yukiko Hiraiwa, Arm R. Amin, Yasuyoshi Sohara, Yuzhen Liu, Satoru Matsuda, Tadashi Yamamoto, and Michinari Hamaguchi

Research from 1999

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Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and its Marker Genes in Cardiac Myocytes, Joseph I. Shapiro, Amir Askari, Zijian Xie, Peter Kometiani, Jie Li, and Jiang Liu