Date of Award

2024

Degree Name

Pharmaceutical Sciences

College

School of Pharmacy

Type of Degree

M.S.

Document Type

Thesis

First Advisor

Dr. Melinda E. Varney, Committee Chairperson

Second Advisor

Dr. Cynthia B. Jones

Third Advisor

Dr. Jeremy McAleer

Abstract

The intestinal tract serves as a host to an extremely complex microbial system. Microbes in the gut regulate their metabolism in response to chemicals generated by other microorganisms as well as nutrition supply from dietary intake. Alterations in gut bacteria have been implicated in the development of metabolic disorders such as obesity and the progression of diseases such as Myelodysplastic syndromes (MDS). Although the cause of obesity is multifactorial, the consumption of high-fat or sugar-rich diets (Western diets) has been proposed as a significant contributor to this global epidemic. Obesity is a major public health concern that has been extensively linked to dysbiosis in the gut. Myelodysplastic Syndromes (MDS) on the other hand, are a group of various hematopoietic conditions arising from ineffective hematopoiesis. Preliminary findings have shown a strong correlation between obesity and the incidence of MDS/Acute Myeloid Leukemia (AML). It has since been hypothesized that obesity and MDS contribute to dysbiosis by increasing the production of inflammatory myeloid cells which has a profound effect on the intestinal lining of the gut in both human and rodent models. Despite this knowledge, the mechanisms modulating diet-induced obesity and microbiota dysbiosis have not been elucidated in detail. Therefore, the objective of this study is to assess the influence of diet-induced obesity on gut flora, and inflammatory myeloid cells in MDS-susceptible mice.

Subject(s)

Microbiomes.

Myelodysplastic syndromes -- Causes.

Obesity -- Complications.

Obesity -- Causes.

Acute Myeloid Leukemia -- Causes.

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